- TyranoBuilder Visual Novel Studio v1.6.0
- Tyto Ecology v1.14.2
- TZOMPANTLI
- U.F.O. K.O. Tower Defense
- Uagi-Saba
- UAYEB
- UAZ Racing 4×4
- UBERMOSH v1.5
- UBERMOSH Vol.3
- UBERMOSH Vol.5
- UBERMOSH Vol.7
- UBERMOSH Vol.7
- UBERMOSH:BLACK
- UBERMOSH:OMEGA
- UBERMOSH:SANTICIDE
- UBERMOSH:WRAITH
- UberSoldier II – Crimes of War
- UBOAT (B124)
- UEFA Euro 2008
- UEFA Euro 2016 France
- uFactory
- Ufflegrim
- UFO – Unfortunately Fortunate Organisms
- UFO2: Extraterrestrials
- UFO: Afterlight (GOG)
- UFO: Aftermath
- UFO: Aftershock
- UFO: Extraterrestrials Gold
- Uganda know de way
- UglyDolls: An Imperfect Adventure
- UIFO DEFENSE HD
- Ukhar v1.1.0
- Ukrainian Ninja
- Uktena
- Ultima 1+2+3 (GOG)
- Ultima 4+5+6 (GOG)
- Ultima 7 The Complete Edition (GOG)
- Ultima 8 Gold Edition (GOG)
- Ultima 9: Ascension (GOG)
- Ultima Underworld 1+2 (GOG)
- Ultima Worlds of Adventure 2: Martian Dreams (GOG)
- Ultimagus
- Ultimate Admiral: Age of Sail
- Ultimate Admiral: Dreadnoughts
- Ultimate ADOM – Caverns of Chaos
- Ultimate ADOM – Caverns of Chaos
- Ultimate Arena v2.0
- ULTIMATE ARENA: SHOWDOWN
- Ultimate Boob Wars!! ~Big Breasts vs Flat Chests~
- Ultimate Booster Experience
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