- Seeds of Resilience v1.0.11
- Seek Etyliv
- Seek Girl (Update May 13, 2019)
- Seek Girl Ⅱ
- Seek Girl Ⅲ
- Seek Girl Ⅳ
- Seek Girl Ⅵ
- Seek Girl Ⅶ
- Seek Girl Ⅷ
- Seek Girl V
- Seek Girl:Fog Ⅰ
- Seek Hearts
- Seeker 2
- Seeking Dawn
- Seeking Evil: The Wendigo
- Seen (Update 9)
- Seers Isle
- SEGA Bass Fishing
- SEGA Genesis Classics Pack 5
- Sega Marine Fishing
- SEGA Mega Drive and Genesis Classics
- SEGA Mega Drive Classics Collection
- Sega Rally Revo
- SEGFAULT
- Seinarukana -The Spirit of Eternity Sword 2-
- Seishin – Virtual Rhythm
- Seiyuu Danshi
- Sekiro: Shadows Die Twice (GOTY Edition v1.06)
- Sekiro: Shadows Die Twice v1.04
- Sekwere
- Selatria: Advent of the Dakk’rian Empire
- Selection Process
- Selenon Rising v1.01
- Selenophobia
- Self Shot
- Self-Isolation
- Selma and the Wisp (Update Jul 19, 2019)
- Semblance
- Semispheres
- SEN: Seven Eight Nine
- Sengoku (GOG)
- Sengoku Jidai Shadow of the Shogun Mandate of Heaven
- Sengoku Neet
- Sengoku Rance
- Sengoku Way Of The Warrior
- Senko no Ronde 2
- SENRAN KAGURA Bon Appétit! – Full Course
- SENRAN KAGURA Burst Re:Newal (v1.06 & ALL DLC)
- SENRAN KAGURA ESTIVAL VERSUS v1.06 (Inclu ALL DLC)
- SENRAN KAGURA Peach Ball
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