- Signal Decay
- Signal Ops (GOG)
- Signal Simulator v1.7.3
- Signal to Noise v1.02
- Signed and Sealed With a Kiss
- Signs of Life v0.15.1
- Signs of the Sojourner
- SIIMI
- Silence (GOG)
- Silence Channel
- Silence in Space – Season One
- Silence in the Dark
- Silence of the Sleep
- Silence The Whispered World 2
- Silenced: The House
- Silent Depth 3D Submarine Simulation
- Silent Descent
- Silent Hill 2: Director’s Cut
- Silent Hill 3
- Silent Hill 4: The Room
- Silent Hill 5 HomeComing
- Silent Hunter 2 (GOG)
- Silent Hunter 3 (Inclu ALL DLC)
- Silent Hunter 4: Wolves of the Pacific
- Silent Hunter 5: Battle of the Atlantic
- Silent Sector
- Silent Storm Gold Edition
- Silent Storm Sentinels
- Silent World
- Silicon City
- Silicon Dreams | cyberpunk interrogation
- SILICON RISING
- Silicon Zeroes v1.2.0.1
- Silk
- Silmaris: Dice Kingdom
- Siluman Fantasy – First Half –
- Silver (GOG)
- Silver Bullet: Prometheus
- Silver Chains
- Silver Grapple
- Silver Knight v1.0.1.9
- Silverfall
- Silverfall Wächter der Elemente
- Silverfall: Earth Awakening
- SilverFrame(纯白星原)
- SilverQuest: Gaiden
- Silverworld
- Sim Junta v1.2.3
- SimAirport (Update Oct 29, 2019)
- SimAnt
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