- Sethian
- Settled
- Settlement Survival
- Settlement Zero
- Settlers of Orion
- SEUM: Speedrunners from Hell (Rev 3319)
- SEUM: The Drunk Side of the Moon
- Seven boys 2
- Seven Days
- Seven days with the Ghost
- Seven Doors
- Seven Kingdoms 2 HD (GOG)
- Seven Kingdoms: Ancient Adversaries (GOG)
- Seven Mysteries: The Last Page
- Seven: Enhanced Edition v1.3.1
- Seven: The Days Long Gone v1.2.0
- Seven: The Days Long Gone v1.3.3
- Seventh Circle
- Severance: Blade of Darkness (GOG)
- Severed Steel
- Sex & Gun PC
- Sex & Gun VR
- Sex Angel Ariel – The Kingdom’s Guardian Angel
- Sex Apartments
- Sex Apocalypse
- Sex Lady Sonia
- Sex Quest
- Sex Simulator 2020
- Sex with Stalin
- Sex with Stalin
- Sex with the Devil
- Sexbot Quality Assurance Simulator
- Sexena: Arena Tales
- Sexorcist Academy
- Sexual Void
- Sexy Beach 3
- Sexy Beach Premium Resort (Inclu DLC)
- Sexy Fitness Girl
- Sexy pharmacist Itori-chan
- Sexy Serial Killer v1.2
- Sexy Sniper
- SFD : Rogue TRPG
- SFD v2.49.2
- SFG Soccer: Football Fever v1.272
- SG/ZH: School Girl/Zombie Hunter
- Shachibato! × Hyperdimension Neptunia Collaboration 2
- Shachibato! President, It’s Time for Battle! Maju Wars
- Shad’O
- Shades of Sakura
- Shadow Blade: Reload
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